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Specimens of M. autumnalis had twice previously been collected, by famous plant hunter J. D. A. Stainton on his 1962 expedition with S. A. Bowes Lyon to central Nepal, and on the Flora of Ganesh Himal expedition undertaken by the University of Tokyo in 1994. However, despite recognition as to the novelty of the plant implicated in Stainon's fieldnotes accompanying the species paratype (where it was described as 'easily distinguishable' from M. paniculata), it was not until new collections and field observations in 2008 that the true status of the plant as a new species was definitely realised. It was formally described in 2011.
M. autumnalis grows in sub-alpine habitat commonly along stream margins, grassy alpine slopes or at edges and openings of Abies forest. Commonly associated herbaceous species include Rumex, Arisaema, Stellaria, Nepeta, Persicaria, Aster, Swertia, as well as dwarf shrubs such as Berberis, Rhododendron and Juniperus. The species ranges in elevation from 3300–4200 m, favouring stony, humus-rich soils. Similar to Meconopsis manasluensis and other Meconopsis of Nepal, the species appears to exhibit a very limited geographic distribution, thus necessitating more in-depth conservation assessment. Flowering occurs in late July to September.
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